Influence of lysophosphatidic acid on estradiol production and follicle stimulating hormone action in bovine granulosa cells.
نویسندگان
چکیده
The objective of the study was to examine the effect of lysophosphatidic acid (LPA) on 17β-estradiol (E2) synthesis and follicle stimulating hormone (FSH) action in bovine granulosa cells. We found that granulosa cells in the bovine antral follicle, in addition to the uterus and the CL, are also the site of LPA synthesis and the target for LPA action in the bovine reproductive tract. Our findings suggest that LPA stimulates E2 synthesis, probably via increased expression of FSHR and 17β-HSD genes.
منابع مشابه
Follicle-stimulating hormone-induced estradiol and progesterone production by bovine antral and mural granulosa cells cultured in vitro in a completely defined medium.
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ورودعنوان ژورنال:
- Reproductive biology
دوره 13 4 شماره
صفحات -
تاریخ انتشار 2013